Allyl bromide → 8-[5-(4-Fluorophenyl)pentan-2-yl]-5,5-dimethyl-10-prop-2-enoxychromeno[4,3-c]pyridine

HRID 126828Notes

Reaction equation

HRID 126828 reaction equation
[CH3:1][C:2]1([CH3:29])[C:24]2=[CH:25][CH:26]=[N:27][CH:28]=[C:23]2[C:5]2[C:6]([OH:22])=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH3:11])=[CH:9][C:4]=2[O:3]1.[CH2:30](Br)[CH:31]=[CH2:32]>>[CH3:29][C:2]1([CH3:1])[C:24]2=[CH:25][CH:26]=[N:27][CH:28]=[C:23]2[C:5]2[C:6]([O:22][CH2:32][CH:31]=[CH2:30])=[CH:7][C:8]([CH:10]([CH2:12][CH2:13][CH2:14][C:15]3[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=3)[CH3:11])=[CH:9][C:4]=2[O:3]1

Participants

3

Reactant 2

HCID 7841Allyl bromideHCID 202878485,5-Dimethyl-8-[5-(4-fluorophenyl)-2-pentyl]-10-hydroxy-5H-[1]benzopyrano[3,4-d]pyridine

Product 1

HCID 3361538-[5-(4-Fluorophenyl)pentan-2-yl]-5,5-dimethyl-10-prop-2-enoxychromeno[4,3-c]pyridine

Procedure

5,5-Dimethyl-8-[5-(4-fluorophenyl)-2-pentyl]-10-(2-propenyloxy)-5H-[1]benzopyrano[3,4-d]pyridine was prepared by reacting 5,5-dimethyl-8-[5-(4-fluorophenyl)-2-pentyl]-10-hydroxy-5H-[1]benzopyrano[3,4-d]pyridine with 2-propenyl bromide following the procedure of Example 51.

Sources & evidence

ORD record
ord-eb5b8b2b689c4890aec1feb379bb73ca
Source dataset
uspto-grants-1981_03
Patent number
US04254116

Reaction notes

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