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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1268286Generated: November 1, 2026

Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → (E)-(S)-Ethyl 3-{4-[3-(3'-Acetyl-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionate

https://huagongshe.com/reaction/1268286

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 9816147—
Reactant(E)-3-(3'-acetyl-biphenyl-4-yl)-but-2-en-1-olHCID 69799799—
Product(E)-(S)-Ethyl 3-{4-[3-(3'-Acetyl-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionateHCID 8658995365.8%

Reaction Steps

The title compound (0.16 g, 65% yield) was prepared from (E)-3-(3′-acetyl-biphenyl-4-yl)-but-2-en-1-ol (0.133 g, 0.50 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (0.125 g, 0.525 mmol) by a procedure analogous to that described in example 52c.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06555577B1
Source datasetuspto-grants-2003_04
ORD IDord-a8ab9ca0c2184d1cab1062ff97e8a3c8
Source noteuspto-grants-2003_04