Ethyl trans-4-Bromocinnamate → HCID 69801209, compound

HRID 1268287Notes

Reaction equation

HRID 1268287 reaction equation
[CH2:1]([O:3][C:4](=[O:14])/[CH:5]=[CH:6]/[C:7]1[CH:12]=[CH:11][C:10](Br)=[CH:9][CH:8]=1)[CH3:2].[CH:15]([C:18]1[CH:19]=[CH:20][C:21]([O:27][CH3:28])=[C:22](B(O)O)[CH:23]=1)([CH3:17])[CH3:16]>>[CH2:1]([O:3][C:4](=[O:14])/[CH:5]=[CH:6]/[C:7]1[CH:12]=[CH:11][C:10]([C:22]2[CH:23]=[C:18]([CH:15]([CH3:17])[CH3:16])[CH:19]=[CH:20][C:21]=2[O:27][CH3:28])=[CH:9][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 688115Ethyl trans-4-BromocinnamateHCID 45891905-Isopropyl-2-methoxyphenylboronic acid

Product 1

HCID 69801209HCID 69801209, compound

Procedure

(E)-3-(4-Bromo-phenyl)-acrylic acid ethyl ester (450 mg, 2.0 mmol) was reacted with 5-isopropyl-2-methoxy-benzene boronic acid (776 mg, 4.0 mmol) by a procedure described in example 52a, to give (E)-3-(5′-Isopropyl-2′-methoxy-biphenyl-4-yl)-acrylic acid ethyl ester.

Sources & evidence

ORD record
ord-f578c77ddac04faeba1b75adf6485012
Source dataset
uspto-grants-2003_04
Patent number
US06555577B1

Reaction notes

Loading…