Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 86589956, compound

HRID 1268305Notes

Reaction equation

HRID 1268305 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](/[C:8](/[CH3:14])=[C:9](/[CH2:12][CH3:13])\[CH2:10][OH:11])=[CH:4][CH:3]=1.[CH2:15]([O:17][C@@H:18]([CH2:24][C:25]1[CH:30]=[CH:29][C:28](O)=[CH:27][CH:26]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH3:16]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5](/[C:8](/[CH3:14])=[C:9](/[CH2:12][CH3:13])\[CH2:10][O:11][C:28]2[CH:27]=[CH:26][C:25]([CH2:24][C@H:18]([O:17][CH2:15][CH3:16])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:30][CH:29]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 69797596HCID 69797596, compound

Product 1

HCID 86589956HCID 86589956, compoundYield 81%

Procedure

The title compound (535 mg, 81%) was prepared from (Z)-3-(4-bromophenyl)-2-ethyl-but-2-en-1-ol (prepared as described in example 96b) (355 mg, 1.39 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (348 mg, 1.46 mmol) by a procedure analogous to that described in example 52c.

Sources & evidence

ORD record
ord-15f95d4ecc9a4dd0851707a6223a6cba
Source dataset
uspto-grants-2003_04
Patent number
US06555577B1

Reaction notes

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