HRID126832

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)C(C)(C)c1ccc(C(=O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl

HCID12939646

Ethyl 2-[4-(4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butanoyl)phenyl]-2-methylpropanoate--hydrogen chloride (1/1)

C34H42ClNO4

结构：CCOC(=O)C(C)(C)c1ccc(C(=O)CCN2CCC(=C(c3ccccc3)c3ccccc3)CC2)cc1.Cl

HCID86737529

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(C)(C)c1ccc(C(O)CCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl

HCID20572717

未命名化合物

PROCEDURE

实验过程

When in the procedure of Example 2 an appropriate amount of ethyl 4-[3-[4-(diphenylmethylene)-1-piperidinyl]-1-oxopropyl]-α,α-dimethylbenzene acetate hydrochloride is substituted for ethyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetate hydrochloride, ethyl 4-[3-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxypropyl]-α,α-dimethylbenzeneacetate hydrochloride is obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7a85e4f985d7478c848b62ad09c91c33
来源数据集: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04254129
来源说明: uspto-grants-1981_03

反应 SMILES

[ClH:1].[C:2]1([C:8]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[C:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([CH3:32])([CH3:31])[C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:21][CH:20]=3)=[O:18])[CH2:11][CH2:10]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[OH:40]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1CCN(CCCC(C2C=CC(C(C)(C)C(OCC)=O)=CC=2)=O)CC1>>[ClH:1].[OH:40][C:8]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH:17]([C:19]2[CH:20]=[CH:21][C:22]([C:25]([CH3:31])([CH3:32])[C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:23][CH:24]=2)[OH:18])[CH2:13][CH2:14]1