Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 86589960, compound

HRID 1268326Notes

Reaction equation

HRID 1268326 reaction equation
[OH:1][CH2:2]/[CH:3]=[C:4](/[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14](/[C:18](/[CH3:25])=[CH:19]/[C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:13]=2)=[CH:8][CH:7]=1)\[CH3:5].[CH2:26]([O:28][C@@H:29]([CH2:35][C:36]1[CH:41]=[CH:40][C:39](O)=[CH:38][CH:37]=1)[C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH3:27]>>[CH2:26]([O:28][C@H:29]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:35][C:36]1[CH:41]=[CH:40][C:39]([O:1][CH2:2]/[CH:3]=[C:4](/[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14](/[C:18](/[CH3:25])=[CH:19]/[C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:13]=3)=[CH:8][CH:7]=2)\[CH3:5])=[CH:38][CH:37]=1)[CH3:27]

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 22557704(E,E)-ethyl 3-[4'-(3-hydroxy-1-methyl-propenyl)-biphenyl-3-yl]-but-2-enoate

Product 1

HCID 86589960HCID 86589960, compoundYield 59%

Procedure

The title compound (230 mg, 58%) was prepared from (E,E)-ethyl 3-[4′-(3-hydroxy-1-methyl-propenyl)-biphenyl-3-yl]-but-2-enoate (235 mg, 0.70 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (175 mg, 0.73 mmol) by a procedure analogous to that described in example 52c.

Sources & evidence

ORD record
ord-1c88cd49009546aea7e98d6d5427d664
Source dataset
uspto-grants-2003_04
Patent number
US06555577B1

Reaction notes

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