Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 86589961, compound

HRID 1268332Notes

Reaction equation

HRID 1268332 reaction equation
[Br:1][C:2]1[CH:3]=[C:4](/[C:9](/[CH3:13])=[CH:10]/[CH2:11][OH:12])[CH:5]=[C:6]([Br:8])[CH:7]=1.[CH2:14]([O:16][C@@H:17]([CH2:23][C:24]1[CH:29]=[CH:28][C:27](O)=[CH:26][CH:25]=1)[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:15]>>[Br:1][C:2]1[CH:3]=[C:4](/[C:9](/[CH3:13])=[CH:10]/[CH2:11][O:12][C:27]2[CH:26]=[CH:25][C:24]([CH2:23][C@H:17]([O:16][CH2:14][CH3:15])[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:29][CH:28]=2)[CH:5]=[C:6]([Br:8])[CH:7]=1

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 69800699HCID 69800699, compound

Product 1

HCID 86589961HCID 86589961, compoundYield 81%

Procedure

The title compound (851 mg, 81%) was prepared from (E)-3-(3,5-dibromo-phenyl)-but-2-en-1-ol (612 mg, 2.0 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (500 mg, 2.10 mmol) by a procedure analogous to that described in example 52c.

Sources & evidence

ORD record
ord-4507f75bce1c49a2abecb0504aace7ab
Source dataset
uspto-grants-2003_04
Patent number
US06555577B1

Reaction notes

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