Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 20765812, compound

HRID 1268339Notes

Reaction equation

HRID 1268339 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[C:15](/[CH:17]=[CH:18]/[CH2:19][OH:20])[CH:14]=[C:13]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([CH3:30])([CH3:29])[CH3:28])=[CH:23][CH:22]=3)[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:31]([O:33][C@@H:34]([CH2:40][C:41]1[CH:46]=[CH:45][C:44](O)=[CH:43][CH:42]=1)[C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH3:32]>>[C:27]([C:24]1[CH:25]=[CH:26][C:21]([C:13]2[CH:14]=[C:15](/[CH:17]=[CH:18]/[CH2:19][O:20][C:44]3[CH:43]=[CH:42][C:41]([CH2:40][C@H:34]([O:33][CH2:31][CH3:32])[C:35]([O:37][CH2:38][CH3:39])=[O:36])=[CH:46][CH:45]=3)[CH:16]=[C:11]([C:8]3[CH:7]=[CH:6][C:5]([C:1]([CH3:3])([CH3:4])[CH3:2])=[CH:10][CH:9]=3)[CH:12]=2)=[CH:22][CH:23]=1)([CH3:30])([CH3:29])[CH3:28]

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 22557706HCID 22557706, compound

Product 1

HCID 20765812HCID 20765812, compoundYield 79.3%

Procedure

The title compound (368 mg, 79%) was prepared from (E)-3-(4,4″di-tert-butyl-[1,1′;3′,1″]terphenyl-5′-yl)-prop-2-en-1-ol (300 mg, 0.75 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (188 mg, 0.79 mmol) by a procedure analogous to that described in example 52c.

Sources & evidence

ORD record
ord-32b64b7b34b84cb0bcf092f6045b2de7
Source dataset
uspto-grants-2003_04
Patent number
US06555577B1

Reaction notes

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