反应详情

A mixture of 1 g of ethyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetate hydrochloride, 25 ml of methanol and 5 ml of 25% sodium hydroxide solution is stirred and refluxed for 2 hours then concentrated to a solid, neutralized with dilute hydrochloric acid and extracted with hot toluene. The toluene extract is filtered and concentrated to a residue which is recrystallized from chloroform/toluene to give 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid.

1. temperaturerefluxed for 2 hours
2. concentrationthen concentrated to a solid, neutralized with dilute hydrochloric acid
3. extractionextracted with hot toluene
4. extractionThe toluene extract
5. filtrationis filtered
6. concentrationconcentrated to a residue which
7. customis recrystallized from chloroform/toluene