Sodium Hydroxide → HCID 69797800, compound

HRID 1268356Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[C:7]([C:15]2[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[CH2:23][O:24][C:25]3[CH:30]=[CH:29][C:28]([CH2:31][C@H:32]([O:38][CH2:39][CH3:40])[C:33]([O:35]CC)=[O:34])=[CH:27][CH:26]=3)=[CH:17][CH:16]=2)[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>>[C:1]([C:5]1[CH:6]=[C:7]([C:15]2[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[CH2:23][O:24][C:25]3[CH:26]=[CH:27][C:28]([CH2:31][C@H:32]([O:38][CH2:39][CH3:40])[C:33]([OH:35])=[O:34])=[CH:29][CH:30]=3)=[CH:17][CH:16]=2)[CH:8]=[C:9]([C:11]([CH3:13])([CH3:14])[CH3:12])[CH:10]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 86589966HCID 86589966, compound

Product 1

HCID 69797800HCID 69797800, compoundYield 89.4%

Procedure

The title compound was prepared from (E)-(S)-ethyl 3-{4-[3-(3′,5′-di-tert-butyl-biphenyl-4-yl)-allyloxy]-phenyl}-2-ethoxy-propionate (example 129) (110 mg, 0.20 mmol) and sodium hydroxide (1M, 0.8 ml, 0.8 mmol) by a procedure analogous to that described in example 51, yielding ((E)-(S)-3-{4-[3-(3′,5′-di-tert-butyl-biphenyl-4-yl)-allyloxy]-phenyl}-2-ethoxy-propionic acid (92 mg, 88%) as a colourless solid.

Sources & evidence

ORD record: ord-17766056465d4bda93e87f3c21f90728
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06555577B1

Reaction notes

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