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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1268360Generated: October 31, 2026

4-Fluorophenylboronic acid → (E)-ethyl 3-(4'-fluoro-biphenyl-4-yl)-but-2-enoate

https://huagongshe.com/reaction/1268360

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorophenylboronic acidHCID 285645—
Reactant(E)-ethyl 3-(4-iodophenyl)-but-2-enoateHCID 11438459—
Product(E)-ethyl 3-(4'-fluoro-biphenyl-4-yl)-but-2-enoateHCID 22557664—

Reaction Steps

The colourless solid (E)-ethyl 3-(4′-fluoro-biphenyl-4-yl)-but-2-enoate was prepared from (E)-ethyl 3-(4-iodophenyl)-but-2-enoate (example 91a) and 4-fluorobenzene boronic acid by a procedure analogous to that described in example 52a.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06555577B1
Source datasetuspto-grants-2003_04
ORD IDord-acf2464f6b624ed3bcecc6a244631575
Source noteuspto-grants-2003_04