HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 3-Carboxy-1-(3-trifluoromethylphenyl)-2-pyrrolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | 1,1-Cyclopropanedicarboxylic acid | HCID 69017 | — |
| Product | 3-Carboxy-1-(3-trifluoromethylphenyl)-2-pyrrolidinone | HCID 15516061 | 38.8% |
Reaction Steps
10.0 g of 1,1-cyclopropanedicarboxylic acid and 12.4 g of 4-trifluoromethylaniline were added to 15 ml of acetonitrile, followed by refluxing for 7 hours with heating and stirring. The subsequent operation was conducted in the same manner as in Example 2 to obtain 7.1 g of an intended compound at a yield of 38.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06555694B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-fe6910e3850d4e9fb582925dc8c69c0b |
| Source note | uspto-grants-2003_04 |