HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1-(4-Chlorophenyl)-3-methylene-2-pyrrolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 4-Methoxypiperidine | HCID 77666 | — |
| Reactant | 1-(4-Chlorophenyl)-2-oxopyrrolidine-3-carboxylic acid | HCID 4057084 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Chlorophenyl)-3-methylene-2-pyrrolidinone | HCID 18544412 | 62.9% |
Reaction Steps
1.56 g of 1-(4-chlorophenyl)-3-carboxy-2-pyrrolidinone was mixed with 7 ml of methanol. Thereto were added 0.26 g of 75% paraformaldehyde and 0.75 g of 4-methoxypiperidine. The mixture was refluxed for 2 hours. The reaction mixture was concentrated to dryness. The residue was purified by silica gel column chromatography using chloroform (a solvent) to obtain 0.85 g of 1-(4-chlorophenyl)-3-methylene-2-pyrrolidinone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06555694B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-f2dee16d260f4c7f86b8b0d451a7f180 |
| Source note | uspto-grants-2003_04 |