Ethanol → 2-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

HRID 1268401Notes

Reaction equation

HRID 1268401 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:16])([CH3:15])[C:13]#[N:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1.C([OH:19])C.O>[OH-].[K+]>[CH:1]1([C:4]([C:6]2[CH:7]=[CH:8][C:9]([C:12]([CH3:16])([CH3:15])[C:13]([NH2:14])=[O:19])=[CH:10][CH:11]=2)=[O:5])[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 702EthanolHCID 962WaterHCID 234998454-(Cyclopropylcarbonyl)-alpha,alpha-dimethylbenzeneacetonitrile

Product 1

HCID 234998512-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent2×

Procedure

Dissolve 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile (100 mg) in aqueous ethanolic potassium hydroxide (2 mL) (prepared from ethanol (5 mL), water (5 mL) and solid potassium hydroxide (1.5 g). Stir overnight at room temperature, then heat at reflux for 6 hours. Cool and evaporate the solvent in vacuo to give the title compound.

Workup

  1. temperatureheat
  2. temperatureat reflux for 6 hours
  3. temperatureCool
  4. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-96131c963eda4048859de523fc3a7ce4
Source dataset
uspto-grants-2003_04
Patent number
US06555689B2

Reaction notes

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