Urea → HCID 20288020, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 50 parts of 2-[(2-amino-4,5-dichlorophenyl)-amino]ethanol and 46 parts of urea is stirred and heated for 2 hours in an oil-bath at about 190° C. The reaction mixture is cooled and water is added. The water is decanted and the residue is boiled in 2-propanol. Upon stirring, the mixture is cooled to room temperature. The product is filtered off and dried, yielding 55 parts (99%) of 5,6-dichloro-1,3-dihydro-1-(2-hydroxyethyl)-2H-benzimidazol-2-one.

Provenance & Evidence