反应详情

A mixture of 200 parts of acetic acid anhydride, 90 parts of ethyl 4-piperidineacetate and 225 parts of methylbenzene is stirred and refluxed for 3 hours. The reaction mixture is evaporated and the residue is diluted with water. The product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 92 parts (82%) of ethyl 1-acetyl-4-piperidineacetate as a residue.

1. temperaturerefluxed for 3 hours
2. customThe reaction mixture is evaporated
3. additionthe residue is diluted with water
4. extractionThe product is extracted with methylbenzene
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated