反应详情

To a stirred solution of 92 parts of ethyl 1-acetyl-4-piperidineacetate in 200 parts of ethanol are added dropwise (slowly) 65 parts of sodium hydroxide solution 30%. Upon completion, stirring is continued for 2 hours in a warm water-bath. The reaction mixture is poured onto water and the whole is filtered over hyflo. The clear filtrate is concentrated to a third of its volume and the concentrate is acidified with a diluted hydrochloric acid solution. While cooling, the product is allowed to crystallize. It is filtered off and dried, yielding 29 parts (36.5%) of 1-acetyl-4-piperidineacetic acid; mp. 124.1° C.

1. additionThe reaction mixture is poured onto water
2. filtrationthe whole is filtered over hyflo
3. concentrationThe clear filtrate is concentrated to a third of its volume
4. temperatureWhile cooling
5. customto crystallize
6. filtrationIt is filtered off
7. customdried