Hydrochloric Acid → HCID 20288026, compound

Participants

Reaction Steps

A mixture of 9 parts of 1-[3-[4-[2-(3-chlorophenyl)-2-oxoethyl]-1-piperidinyl]propyl]-1,3-dihydro-3-(1-methylethenyl)-2H-benzimidazol-2-one, 18 parts of a concentrated hydrochloric acid, 80 parts of ethanol and 50 parts of water is stirred for 30 minutes at room temperature. The reaction mixture is evaporated and water is added to the residue. The free base is liberated in the conventional manner with ammonium hydroxide and extracted with trichloromethane. The extract is dried, filtered and evaporated. The oily residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol (90:10 by volume) as eluent. The pure fractions are collected and the eluent is evaporated. The residue is crystallized from 4-methyl-2-pentanone. The product is filtered off and dried, yielding 6.4 parts (78%) of 1 -[3-[4-[2-(3-chlorophenyl)-2-oxoethyl]-1-piperidinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one; mp. 160.3° C.

Provenance & Evidence