Methanesulfonyl chloride → HCID 22344417, compound

HRID 1268792Notes

Reaction equation

HRID 1268792 reaction equation
[CH2:1]([C:7]1[N:8]([CH2:20][CH2:21][CH2:22][CH2:23][NH2:24])[C:9]2[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]=[CH:11][C:10]=2[N:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH3:25][S:26](Cl)(=[O:28])=[O:27]>>[CH2:1]([C:7]1[N:8]([CH2:20][CH2:21][CH2:22][CH2:23][NH:24][S:26]([CH3:25])(=[O:28])=[O:27])[C:9]2[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[N:12]=[CH:11][C:10]=2[N:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 223444374-(2-Hexyl-1H-imidazo[4,5-c]quinolin-1-yl)butan-1-amine

Product 1

HCID 22344417HCID 22344417, compoundYield 92.2%

Procedure

Using the general method of Example 232, 4-(2-hexyl-1H-imidazo[4,5-c]quinolin-1-yl)butan-1-amine (1.00 g, 3.1 mmol) was reacted with methanesulfonyl chloride (0.48 mL, 6.2 mmol) to provide 1.15 g of N-[4-(2-hexyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide as a white solid.

Sources & evidence

ORD record
ord-8854f8eb4ea8459cb51dea8be92657b6
Source dataset
uspto-grants-2007_04
Patent number
US07199131B2

Reaction notes

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