Methanesulfonyl chloride → HCID 10045140, compound

HRID 1268798Notes

Reaction equation

HRID 1268798 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:17]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:10]=[C:9]([NH2:18])[C:8]=2[N:7]=[C:6]1[CH2:19][CH2:20][O:21][CH3:22].[CH3:23][S:24](Cl)(=[O:26])=[O:25]>>[NH2:18][C:9]1[C:8]2[N:7]=[C:6]([CH2:19][CH2:20][O:21][CH3:22])[N:5]([CH2:4][CH2:3][CH2:2][NH:1][S:24]([CH3:23])(=[O:26])=[O:25])[C:17]=2[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N:10]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 223444281-(3-aminopropyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine

Product 1

HCID 10045140HCID 10045140, compound

Procedure

Using the general method of Example 242, 1-(3-aminopropyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.53 g, 5.11 mmol) was reacted with methanesulfonyl chloride to provide 800 mg of N-{3-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}methanesulfonamide as light yellow needles, m.p. 193–194° C. Analysis: Calculated for C17H23N5O3S: % C, 54.09; % H, 6.14; % N, 18.55. Found: % C, 54.09; % H, 5.93; % N, 18.49.

Sources & evidence

ORD record
ord-741fed272eed4912a3983b07c6ec73f4
Source dataset
uspto-grants-2007_04
Patent number
US07199131B2

Reaction notes

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