Dansyl chloride → HCID 10346982, compound

Participants

Reaction Steps

Using the general method of Example 245 except that chloroform was used as the solvent, 1-(3-aminopropyl)-2-(methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.53 g, 5.11 mmol) was reacted with 5-dimethylamino-1-naphthalenesulfonyl chloride (5.87 mmol) to provide 1.45 g of N-{3-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-5-(dimethylamino)naphthalene-1-sulfonamide as a yellow solid, m.p. 210–215° C. Analysis: Calculated for C28H32N6O3S.1.50H2O: % C, 60.09; % H, 6.30; % N, 15.02. Found: % C, 59.89; % H, 6.22; % N, 14.86.

Provenance & Evidence