反应详情

温度

70 °C

13.0 g (40.0 mmol) of caesium carbonate are added to a solution of 7.40 g (26.6 mmol) of N-(4-nitrophenyl)-3-chloropropane-1-sulfonamide in 150 ml of acetonitrile, and the mixture is stirred at 70° C. for 18 hours. The reaction mixture is subjected to conventional work-up, and the crude product is chromatographed on a silica-gel column using ethyl acetate/petroleum ether as eluent, giving 2-(4-nitrophenyl)isothiazolidine 1,1-dioxide as a yellowish solid; ESI 243.

1. customthe crude product is chromatographed on a silica-gel column