反应详情

1.5 g of water-moist Raney nickel, 0.5 ml of glacial acetic acid and 0.5 ml of water are added to a solution of 200 mg (0.425 mmol) of 2-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-N-[4-(1,1-dioxoisothiazolidin-2-yl)phenyl]-valeramide in 10 ml of methanol, and the mixture is hydrogenated. The reaction mixture is filtered, and the filtrate is evaporated, giving 2-(3-amidinophenoxy)-N-[4-(1,1-dioxoisothiazolidin-2-yl)phenyl]valeramide, acetate (“AA”) as a colourless solid; ESI 431.

1. filtrationThe reaction mixture is filtered
2. customthe filtrate is evaporated