2-Methyl-4-nitroaniline → HCID 17988813, compound

HRID 1268822Notes

Reaction equation

HRID 1268822 reaction equation
[CH3:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[Cl:12][CH2:13][CH2:14][CH2:15][S:16](Cl)(=[O:18])=[O:17]>N1C=CC=CC=1>[CH3:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][S:16]([CH2:15][CH2:14][CH2:13][Cl:12])(=[O:18])=[O:17]

Participants

4

Reactant 2

HCID 74412-Methyl-4-nitroanilineHCID 154103-Chloropropanesulphonyl chloride

Product 1

HCID 17988813HCID 17988813, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 5.51 g (36.2 mmol) of 2-methyl-4-nitroaniline and 6.41 g (36.2 mmol) of 3-chloropropanesulfonyl chloride in 20 ml of pyridine is stirred overnight at room temperature. The reaction mixture is then poured onto ice. The precipitate which deposits in the process is filtered off with suction and dried, giving N-(2-methyl-4-nitrophenyl)-3-chloropropane-1-sulfonamide as a yellowish solid; ESI 293.

Workup

  1. additionThe reaction mixture is then poured onto ice
  2. filtrationis filtered off with suction
  3. customdried

Sources & evidence

ORD record
ord-aaa7469ed2bb4b839ca2aa8ad1a3a142
Source dataset
uspto-grants-2007_04
Patent number
US07199133B2

Reaction notes

Loading…