Ammonia → HCID 10183315, compound

Participants

Reaction Steps

200 mg of water-moist Raney nickel and 1.0 ml of methanolic ammonia solution are added to a solution of 200 mg (0.434 mmol) of 2-(3-cyanophenylamino)-N-[4-(1,1-dioxoisothiazolidin-2-yl)-3-methylphenyl]-2-phenylacetamide in 3 ml of methanol, and the mixture is hydrogenated at 50° C. The reaction mixture is filtered, and the filtrate is evaporated, giving 2-(3-aminomethylphenylamino)-N-[4-(1,1-dioxoisothiazolidin-2-yl)-3-methylphenyl]-2-phenylacetamide as a colourless solid; ESI 465.

Provenance & Evidence