HCID 58840906, compound → HCID 58840911, compound

Participants

Reaction Steps

To a stirring solution of (7S)-7-benzyloxycarbonylamino-7-(quinolin-6-ylcarbamoyl)-heptanoic acid tert-butyl ester (11.0 g, 21.8 mmol) in EtOAc and MeOH was added 10% Pd/C. The reaction was charged with H2, degassed and refilled with hydrogen three times. The slurry was stirred at RT for 2 h at balloon pressure, then filtered through a plug of Celite, and solvent was removed under reduced pressure. The hydrogenolysis of the ester yielded 8.0 g (99%) of a thick oil solid after 19 h. 1H NMR (CDCl3) δ 8.9–7.3 (7H, m), 3.96 (1H, m), 2.31 (2H, t), 2.0–1.2 (17H, m). MS (ESI): (MH+) 372.2.

Provenance & Evidence