Sodium Carbonate → 4-Amino-2-[5-(cyano-vinyl)-thiophen-3-yl]-thieno[3,2-c]pyridine-7-carboxylic acid amide

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Reaktionsgleichung

Br[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]#[N:10])[S:5][CH:6]=1.[K].B1(B2OC(C)(C)C(C)(C)O2)OC(C)(C)C(C)(C)O1.[NH2:30][C:31]1[C:36]2[CH:37]=[C:38](Br)[S:39][C:35]=2[C:34]([C:41]([NH2:43])=[O:42])=[CH:33][N:32]=1.C([O-])([O-])=O.[Na+].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CN(C=O)C>[NH2:30][C:31]1[C:36]2[CH:37]=[C:38]([C:2]3[CH:3]=[C:4]([CH:7]=[CH:8][C:9]#[N:10])[S:5][CH:6]=3)[S:39][C:35]=2[C:34]([C:41]([NH2:43])=[O:42])=[CH:33][N:32]=1

Komponenten

Reaktionsbedingungen

Temperatur: 100 °C

Versuchsvorschrift

A mixture of 3-(4-bromo-thiophen-2-yl)-acrylonitrile 76 (0.33 g, 1.55 mmol), potassium acatete (0.47 g, 4.74 mmol), bis(pinacolato)diboron (0.84 g, 3.3 mmol), Pd(PPh3)4 (0.12 g, 0.1 mmol), and DMF (11 mL) was heated at 100° C. under nitrogen for 1 h. 4-Amino-2-bromo-thieno[3,2-c]pyridine-7-carboxylic acid amide 17 (0.28 g, 1.0 mmol), 2 M aqueous Na2CO3 solution (3.6 mL), and Pd(PPh3)4 (0.12 g, 0.1 mmol) were added. The reaction mixture was then heated at 100° C. under nitrogen until completion of the reaction (approx. 1 h), cooled to room temperature and concentrated in vacuo to approx. half volume. The mixture was diluted with water (20 mL) and the precipitate of 77 that formed was collected by filtration, washed with MeOH, and dried. 4-amino-2-[5-(cyanovinyl)-thiophen-3-yl]-thieno[3,2-c]pyridine-7-carboxylic acid amide 77 was then dissolved in pyridine (5 mL) and EtOH (1 mL). To the resulting solution was added NaBH4 (0.16 g, 4.1 mmol). The solution was then heated at 100° C. until completion of the reaction (approx. 2 h) and then concentrated in vacuo. The crude product was purified by silica gel column chromatography (eluent: 80% of CH2Cl2:MeOH:NH4OH (89:9:1) in CH2Cl2). The major fractions were combined and concentrated to give 78 (0.12 g) as a pale-yellow solid. 1H NMR (400 MHz, d6-DMSO) δ: 8.48 (s, 1H), 7.90 (br.s, 1H), 7.86 (s, 1H), 7.65 (d, J=1.4 Hz, 1H), 7.31 (s, 1H), 7.26 (br s, 1H), 7.12 (s, 2H), 3.17 (t, 2H), 2.92 (t, 2H). MS (EI) m/z (M+H+) 329 and (M+Na+) 351.

Aufarbeitung

temperatureThe reaction mixture was then heated at 100° C. under nitrogen until completion of the reaction (approx. 1 h)
temperaturecooled to room temperature
concentrationconcentrated in vacuo to approx. half volume
additionThe mixture was diluted with water (20 mL)

Quellen und Nachweise

ORD-Eintrag: ord-bdb0f6d073754e069a7c6767baf770cb
Quelldatensatz: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07199119B2

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