p-Toluenesulfonic acid → 4-{[3-Methoxy-5-(trifluoromethyl)phenyl]amino}-3-penten-2-one

Beteiligte Stoffe

Reaktionsschritte

1.57 g (15.7 mmol) Acetylacetone, 3.00 g (15.7 mmol) 3-methoxy-5-(trifluoromethyl)aniline, and 0.1 g (1.6 mmol) 4-toluenesulfonic acid are dissolved in 150 ml toluene. The reaction mixture is refluxed for 7 h with a Dean-Stark trap to remove water. After cooling down to room temperature, the suspension is filtered. The solid is purified by recrystallisation from ethanol.

Herkunft & Nachweise