Trifluoroacetic acid → HCID 10287760, compound

Participants

Reaction Steps

100 mg (0.46 mmol) Ethyl(2E)-3-{[3-(methyl)phenyl]amino}-2-butenoate, 75 mg. (0.57 mmol) 4-cyanobenzaldehyde, 38 mg (0.38 mmol) 2,4-pentanedione, and 87 mg (0.76 mmol) trifluoroacetic acid are dissolved in 2 ml diisopropyl ether. The reaction mixture is stirred under reflux overnight. After cooling down to room temperature, the solvent is removed in vacuo and the residue is purified by preparative HPLC.

Provenance & Evidence