Triphenylphosphine → HCID 18446920, compound

Participants

Reaction Conditions

Reaction Steps

Palladium acetate (0.025 g, 0.11 mmol) and triphenylphosphine (0.06 g, 0.22 mmol) were suspended in toluene (1 ml). 5-bromoindanone (240 mg, 1.1 mmol) was then added and the mixture heated to 100° C. for 5 min. The solution was then treated with a solution of the product of Step 3 (0.6 g, 0.94 mmol) in toluene (1 ml) and stirred for 18 hours at 100° C. After cooling the solvent was removed in vacuo and the residue purified by silica gel chromatography, eluting with ethyl acetate to afford the title compound (0.25 g, 55%) as a yellow solid; MS(AP+) m/e 482 [M+H]+. Step 5: 5-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-indan-1-one

Provenance & Evidence