Sodium Hydroxide → HCID 74020542, compound

HRID 1268938Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[N:16][O:17][CH2:18][CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([O:34][C:35]4[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=4)[C:29]([O:31]CC)=[O:30])=[CH:23][CH:22]=3)[CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[N:16][O:17][CH2:18][CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([O:34][C:35]4[CH:36]=[CH:37][C:38]([F:41])=[CH:39][CH:40]=4)[C:29]([OH:31])=[O:30])=[CH:23][CH:22]=3)[CH3:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 86591437HCID 86591437, compound

Product 1

HCID 74020542HCID 74020542, compound

Procedure

The target compound (1.13 g) was obtained as colorless crystals by carrying out the reaction and the post-treatment according to Reference example 3 using ethyl 3-[4-[2-[[1-(4′-fluoro-4-biphenylyl)ethylidene]aminoxy]ethoxy]phenyl]-2-(4-fluorophenoxy)propionate (1.44 g) obtained from Reference example 4 and an aqueous sodium hydroxide solution (1N, 5.0 ml).

Workup

customthe reaction

Sources & evidence

ORD record: ord-1a70ec0fc65749379b292632503d9540
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07199139B2

Reaction notes

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