Tetrabutylammonium Fluoride → HCID 86591438, compound

Participants

Reaction Steps

The reaction was carried out according to Reference example 7 using 2-trimethylsilylethyl (S)-3-[4-[2-[[1-(4-biphenylyl)ethylidene]aminoxy]ethoxy]phenyl]-2-(4-t-butylphenoxy)propionate (300 mg) obtained from Reference example 10 and a 1M solution of tetrabutylammonium fluoride in tetrahydrofuran (1.20 ml). The resulting residue was purified by chromatography on a silica gel column (eluant; methylene chloride/methanol=24/1˜19/1), and then the obtained compound was filtered off and washed with isopropyl ether and hexane to afford the target compound (170 mg) as colorless crystals.

Provenance & Evidence