Tetrabutylammonium Fluoride → HCID 86591440, compound

HRID 1268941Notes

Reaction equation

[C:1]1([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH:6]=[CH:5][C:4]([C:7](=[N:9][O:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C@H:21]([O:31][C:32]3[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=3)[C:22]([O:24]CC[Si](C)(C)C)=[O:23])=[CH:16][CH:15]=2)[CH3:8])=[CH:3][CH:2]=1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>>[C:1]1([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH:2]=[CH:3][C:4]([C:7](=[N:9][O:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C@H:21]([O:31][C:32]3[CH:33]=[CH:34][C:35]([F:38])=[CH:36][CH:37]=3)[C:22]([OH:24])=[O:23])=[CH:16][CH:15]=2)[CH3:8])=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 2724141Tetrabutylammonium Fluoride

HCID 86591441HCID 86591441, compound

Product 1

HCID 86591440HCID 86591440, compound

Procedure

The target compound (568 mg) was obtained as colorless crystals by carrying out the reaction and the post-treatment according to Reference example 7 using 2-trimethylsilylethyl (S)-3-[4-[2-[[1-(4-biphenylyl)ethylidene]aminoxy]ethoxy]phenyl]-2-(4-fluorophenoxy)propionate (938 mg) obtained from Reference example 14 and a 1M solution of tetrabutylammonium fluoride in tetrahedrofuran (3.8 ml).

Workup

customthe reaction
customobtained from Reference example 14

Sources & evidence

ORD record: ord-01a1e4433cee47789a437e531af9e745
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07199139B2

Reaction notes

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