反应详情

To a solution of (S)-4-benzyl-3-[(2S,3R)-3-(4-benzyloxyphenyl)-3-hydroxy-2-(4-methylphenoxy)propionyl]oxazolidin-2-one (9.80 g) obtained from Reference example 20(b) in ethanol (150 ml) was added 5% palladium-charcoal (1.00 g), and the reaction solution was stirred at 50° C. for 4 hours in an atmosphere of hydrogen. After the catalyst was removed by filtration, the filtrate was concentrated under reduced pressure. Water was added to the residue, and the resulting solution was extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate, and then the target compound (9.10 g) was obtained as a foam.

1. customAfter the catalyst was removed by filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionWater was added to the residue
4. extractionthe resulting solution was extracted with ethyl acetate
5. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate