HCID 69504523, compound → HCID 69504560, compound

HRID 1268956Notes

Reaction equation

HRID 1268956 reaction equation
[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:40])[C@@H:15]([O:32][C:33]1[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=1)[C@@H:16]([C:18]1[CH:23]=[CH:22][C:21]([O:24]CC2C=CC=CC=2)=[CH:20][CH:19]=1)[OH:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:40])[C@@H:15]([O:32][C:33]1[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=1)[C@H:16]([OH:17])[C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 69504523HCID 69504523, compound

Product 1

HCID 69504560HCID 69504560, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The target compound (1.94 g) was obtained as a foam by carrying out the reaction and the post-treatment according to Reference example 20(c) using (S)-4-benzyl-3-[(2S,3R)-3-(4-benzyloxyphenyl)-2-(4-fluorophenoxy)-3-hydroxypropionyl]oxazolidin-2-one (2.33 g) obtained from Reference example 22(b) and palladium-charcoal (5%, 490 mg).

Workup

  1. customthe reaction

Sources & evidence

ORD record
ord-4f05ab424cbb4ea09c2d2711b3382332
Source dataset
uspto-grants-2007_04
Patent number
US07199139B2

Reaction notes

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