Hydrogen Bromide → HCID 18625989, compound

Participants

Reaction Steps

To a hydrogen bromide.acetic acid solution (25%, 70 ml) was added ethyl 3-(4-benzyloxyphenyl)-2-(4-fluorophenoxy)propionate (7.00 g) obtained from Reference example 25(a), and the reaction solution was stirred for 3 hours at room temperature. The reaction solution was concentrated under reduced pressure, then the residue was dissolved in ethanol (70 ml), and potassium carbonate (6.90 g) was added thereto followed by stirring for 4 hours at room temperature. The reaction solution was concentrated under reduced pressure, and the residue was partitioned between ethyl acetate and water. The separated ethyl acetate layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by chromatography on a silica gel-column (eluant; hexane/ethyl acetate=9/1˜4/1) to give the target compound (2.75 g) as a white powder.

Provenance & Evidence