反应详情

(5R)-3-[4-(3,6-Dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-azidomethyloxazolidin-2-one (2.3 g, 6.5 mmol) (see WO 01/81350) was dissolved in methanol/ethylacetate (1:1, 100 ml) and sodium periodate (1.75 g, 8.2 mmol) dissolved in water (20 ml) was added dropwise over 1 hour. The reaction mixture was stirred for 7 hours at room temperature, filtered to remove most of the salts and the methanol was evaporated under vacuum. The aqueous solution thus obtained was extracted with ethylacetate, dried over sodium sulfate and evaporated to dryness. The residue was subjected to chromatography on silica gel with acetone/hexane (2:1) to give 2.18 g of the product.

1. additionwas added dropwise over 1 hour
2. filtrationfiltered
3. customto remove most of the salts
4. customthe methanol was evaporated under vacuum
5. customThe aqueous solution thus obtained
6. extractionwas extracted with ethylacetate
7. dry with materialdried over sodium sulfate
8. customevaporated to dryness