Sodium hydride → HCID 10217848, compound

Participants

Reaction Steps

(5R)-3-[4-(1,1-Dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-[(diphenoxyphosphinyl)oxymethyl]-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one (Example 15) (0.125 g, 0.19 mmol) was added to a solution of 2-mercaptoimidazole (38 mg, 0.38 mmol) in DMF (2 ml) and the resulting solution was added to a suspension of sodium hydride (15 mg, 0.38 mmol) in DMF (2 ml). The reaction mixture was stirred for 30 minutes and then quenched with excess of aqueous sodium bicarbonate. The mixture was extracted with ethyl acetate, was washed with sodium bicarbonate, water and brine, dried over sodium sulfate and concentrated in vacuo to give 40 mg (42%) of the title compound as a colourless solid.

Provenance & Evidence