1-CHLORO-1-ETHENESULFONYL CHLORIDE → HCID 10151157, compound

Participants

Reaction Steps

(5R)-3-[4-(1,1-Dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-(azidomethyl)oxazolidin-2-one (Reference Example 2) (1.0 g, 2.7 mmol) and 1-chloro-1-ethenesulfonyl chloride (Intermediate 4) (1.1 g, 6.8 mmol) were heated to 90° C. for one hour with stirring. The reaction mixture was cooled to room temperature, diluted with dichloromethane (10 ml) and applied onto a silica gel column. Elution with hexanes/acetone (1.5:1) gave 0.745 g (64%) of the title compound as a colourless solid.

Provenance & Evidence