Hydrochloric Acid → HCID 10127215, compound

Participants

Reaction Steps

(5R)-3-[4-(1,1-Dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-5-[4-(3-(trimethylsilyl)-2-propynyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one (251 mg, 0.5 mmol) (Intermediate 5) was dissolved in methanol (10 ml). Potassium hydroxide (1 M, 0.75 ml) was added and the mixture was stirred at room temperature for 4 hours. Aqueous HCl (2M, 0.5 ml) was added, the excess of methanol was evaporated and the residue was extracted with dichloromethane, dried over magnesium sulfate and concentrated to give the title product (220 mg).

Provenance & Evidence