HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 10217340, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 10217041 | HCID 10217041 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10217340 | HCID 10217340 | 91.3% |
Reaction Steps
(5R)-3-[4-(1,1-Dioxo-3,6-dihydro-2H-thiopyran-4-yl)-3,5-difluorophenyl]-5-[4-(2-hydroxyethyl)-1,2,3-triazol-1-ylmethyl]oxazolidin-2-one (Example 51) (300 mg, 0.66 mmol) was reacted with thionylchloride (78.5 mg, 1.98 mmol) as described for Example 52. Chromatography on silica gel with 2.5% methanol in dichloromethane gave the title compound (285 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07199143B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-f921e63adfb24b7789ea0eed7b728bc3 |
| Source note | uspto-grants-2007_04 |