Hydrochloric Acid → methyl (2S,3S)-3-hydroxypyrrolidine-2-carboxylate hydrochloride

Participants

Reaction Steps

Part A. Hydrogen chloride gas was bubbled into a stirred suspension of trans-3-hydroxy-L-proline (25 g, 190 mmol) in MeOH (250 mL) at 0° C. for 10 min. The resulting clear solution was capped and stirred at room temperature for 6 h. It was concentrated under reduced pressure. The resulting white solids were triturated with either, filtered, and dried under vacuum to give (2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride salt (32.5 g, yield: 93.7%).

Provenance & Evidence