Sodium ethanethiolate → HCID 11397140, compound

HRID 1269007Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16]O)[CH2:10][CH:9]1[C:18](=[O:35])[NH:19][CH:20]([CH:24]1[CH:29]([OH:30])[CH:28]([OH:31])[CH:27]([OH:32])[CH:26]([S:33][CH3:34])[O:25]1)[CH:21]([CH3:23])[CH3:22])=O)(C)(C)C.[CH2:36]([S-:38])[CH3:37].[Na+]>>[CH3:22][CH:21]([CH3:23])[CH:20]([NH:19][C:18]([CH:9]1[CH2:10][CH:11]([CH2:14][CH2:15][CH2:16][S:38][CH2:36][CH3:37])[CH2:12][CH2:13][NH:8]1)=[O:35])[CH:24]1[CH:29]([OH:30])[CH:28]([OH:31])[CH:27]([OH:32])[CH:26]([S:33][CH3:34])[O:25]1

Participants

Reactant 2

HCID 4459711Sodium ethanethiolate

HCID 69220795HCID 69220795, compound

Product 1

HCID 11397140HCID 11397140, compound

Procedure

The title compound of example 22 was prepared from protected tosylate intermediate prepared in example 19, according to the procedure used in examples 19–21, using sodium ethanethiolate in the displacement step; MS (ESPOS): 465.3 [M+H]+.

Sources & evidence

ORD record: ord-4994f61edfc34fdfaa3be4b2c85488e4
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07199106B2

Reaction notes

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