Sodium Cyanide → HCID 11224150, compound

HRID 1269008Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16]O)[CH2:10][CH:9]1[C:18](=[O:35])[NH:19][CH:20]([CH:24]1[CH:29]([OH:30])[CH:28]([OH:31])[CH:27]([OH:32])[CH:26]([S:33][CH3:34])[O:25]1)[CH:21]([CH3:23])[CH3:22])=O)(C)(C)C.[C-:36]#[N:37].[Na+]>>[CH3:22][CH:21]([CH3:23])[CH:20]([NH:19][C:18]([CH:9]1[CH2:10][CH:11]([CH2:14][CH2:15][CH2:16][C:36]#[N:37])[CH2:12][CH2:13][NH:8]1)=[O:35])[CH:24]1[CH:29]([OH:30])[CH:28]([OH:31])[CH:27]([OH:32])[CH:26]([S:33][CH3:34])[O:25]1

Participants

Reactant 2

HCID 8929Sodium Cyanide

HCID 69220795HCID 69220795, compound

Product 1

HCID 11224150HCID 11224150, compound

Procedure

The title compound of example 23 was prepared from protected tosylate intermediate prepared in example 19, 11h according to the procedure used in examples 19–21 using sodium cyanide nucleophile in the displacement step; MS (ESPOS): 430.3 [M+H]+.

Sources & evidence

ORD record: ord-b9b1fd4515914f5398c6384be0d0f730
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07199106B2

Reaction notes

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