Butylamine → HCID 10238998, compound

HRID 1269043Notes

Reaction equation

HRID 1269043 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([C:20]3[CH:25]=[CH:24][N:23]=[C:22](S(C)=O)[N:21]=3)[C:10]([C:11]3[CH:16]=[CH:15][N:14]=[C:13](S(C)=O)[N:12]=3)=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH2:29]([NH2:33])[CH2:30][CH2:31][CH3:32]>>[CH2:29]([NH:33][C:2]1[N:7]2[N:8]=[C:9]([C:20]3[CH:25]=[CH:24][N:23]=[C:22]([NH:8][CH2:9][CH2:10][CH2:11][CH3:16])[N:21]=3)[C:10]([C:11]3[CH:16]=[CH:15][N:14]=[C:13]([NH:7][CH2:6][CH2:5][CH2:4][CH3:3])[N:12]=3)=[C:6]2[CH:5]=[CH:4][CH:3]=1)[CH2:30][CH2:31][CH3:32]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 18446631HCID 18446631, compound

Product 1

HCID 10238998HCID 10238998, compound

Procedure

N-Butyl-2,3-bis[2-(butylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine was prepared by treating 7-chloro-2,3-bis[2-(methylsulfinyl)pyrimidin-4-yl]pyrazolo[1,5-a]pyridine with n-butylamine as described in Example 7. 1H NMR, (400 MHz, CDCl3): δ 8.35 (d, 1H), 8.09 (d, 1H), 7.62 (d, 1H), 7.30 (t, 1H), 6.93 (m, 1H), 6.57 (d, 1H), 6.40 (d, 1H), 6.20 (d, 1H), 5.17 (m, 1H), 5.08 (m, 1H), 3.34–3.46 (m, 6H), 1.75 (m, 2H), 1.35–1.66 (m, 10H), 0.90–1.00 (m, 9H); MS m/z 488 (M+1).

Sources & evidence

ORD record
ord-5ee91789f42045788eff1db05efd677e
Source dataset
uspto-grants-2007_04
Patent number
US07199120B2

Reaction notes

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