Cyclopropylamine → HCID 10173581, compound

HRID 1269044Notes

Reaction equation

HRID 1269044 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([C:20]3[CH:25]=[CH:24][N:23]=[C:22](S(C)=O)[N:21]=3)[C:10]([C:11]3[CH:16]=[CH:15][N:14]=[C:13](S(C)=O)[N:12]=3)=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH:29]1([NH2:32])[CH2:31][CH2:30]1>>[CH:29]1([NH:32][C:2]2[N:7]3[N:8]=[C:9]([C:20]4[CH:25]=[CH:24][N:23]=[C:22]([NH:32][CH:29]5[CH2:31][CH2:30]5)[N:21]=4)[C:10]([C:11]4[CH:16]=[CH:15][N:14]=[C:13]([NH:32][CH:29]5[CH2:31][CH2:30]5)[N:12]=4)=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 18446631HCID 18446631, compound

Product 1

HCID 10173581HCID 10173581, compound

Procedure

N-Cyclopropyl-2,3-bis[2-(cyclopropylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine was prepared by treating 7-chloro-2,3-bis[2-(methylsulfinyl)pyrimidin-4-yl]pyrazolo[1,5-a]pyridine with cyclopropylamine as described in Example 7. 1H NMR, (CDCl3): δ 8.47 (d, 1H), 8.19 (d, 1H), 7.86 (d, 1H), 7.37 (t, 1H), 7.04 (d, 1H), 6.71 (d, 1H), 6.44 (d, 1H), 6.36 (s, 1H), 5.53 (s, 1H), 5.39 (s, 1H), 2.62–290 (m, 3H), 0.77–0.96 (m, 8H), 0.56–0.70 (m, 4H); MS m/z 440 (M+1).

Sources & evidence

ORD record
ord-9c8e16b27810401bb3e4ff5c7f45b436
Source dataset
uspto-grants-2007_04
Patent number
US07199120B2

Reaction notes

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