Isopropylamine → HCID 10238382, compound

HRID 1269047Notes

Reaction equation

Cl[C:2]1[N:7]2[N:8]=[C:9]([C:20]3[CH:25]=[CH:24][N:23]=[C:22](S(C)=O)[N:21]=3)[C:10]([C:11]3[CH:16]=[CH:15][N:14]=[C:13](S(C)=O)[N:12]=3)=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH:29]([NH2:32])([CH3:31])[CH3:30]>>[CH:29]([NH:32][C:2]1[N:7]2[N:8]=[C:9]([C:20]3[CH:25]=[CH:24][N:23]=[C:22]([NH:21][CH:20]([CH3:25])[CH3:9])[N:21]=3)[C:10]([C:11]3[CH:16]=[CH:15][N:14]=[C:13]([NH:7][CH:6]([CH3:10])[CH3:5])[N:12]=3)=[C:6]2[CH:5]=[CH:4][CH:3]=1)([CH3:31])[CH3:30]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 18446631HCID 18446631, compound

Product 1

HCID 10238382HCID 10238382, compound

Procedure

N-Isopropyl-2,3-bis[2-(isopropylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine was prepared by treating 7-chloro-2,3-bis[2-(methylsulfinyl)pyrimidin-4-yl]pyrazolo[1,5-a]pyridine with isopropylamine as described in Example 7. 1H NMR, (CDCl3): δ 8.39 (d, 1H), 8.14 (d, 1H), 7.52 (m, 1H), 7.36 (d, 1H), 6.96 (m, 1H), 6.60 (d, 1H), 6.06 (d, 1H), 5.99 (d, 1H), 5.08 (m, 1H), 4.99 (m, 1H), 4.05–4.25 (m, 2H), 3.80–3.99 (m, 1H), 1.42 (d, 6H), 1.30 (d, 6H), 1.24 (m, 6H); MS m/z 446 (M+1).

Sources & evidence

ORD record: ord-063236411bd64864b4e27fb78be67b78
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07199120B2

Reaction notes

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