HCID 10308898, compound → HCID 10194095, compound

Participants

Reaction Conditions

Reaction Steps

4-[2-(2-Fluoro-4-pyridinyl)pyrazolo[1,5-a]pyridin-3-yl]-N-isopropyl-2-pyrimidinamine (80 mg, 0.23 mmol) was dissolved in isopropylamine (10 mL) in a pressure vessel and the resulting solution heated at 120° C. for 4 days. The resulting mixture was concentrated to a solid that was purified by by silica gel chromatography (1:1 ethyl acetate:hexane) to give 50 mg (56%) of the title compound as a solid. 1H NMR (CDCl3): δ 8.53 (d, 1H), 8.43 (d, 1H), 8.1.5 (two d, 2H), 7.35 (t, 1H), 6.96 (t, 1H), 6.82 (d, 1H), 6.65 (s, 1H), 6.50 (d, 1H), 5.08 (d, 1H), 4.60 (d, 1H), 4.25 (m, 1H), 3.94 (m, 1H), 1.33 (d, 6H), 1.25 (d, 6H); MS m/388 (M+1).

Provenance & Evidence