HCID 18446638, compound → HCID 10310134, compound

Participants

Reaction Steps

N-Cyclopentyl-3-(2-fluoro-4-pyridinyl)-2-(2-furyl)pyrazolo[1,5-a]pyridin-7-amine (0.05 g, 0.02 mmol) was dissolved in cyclopentylamine (1 mL and heated) in a 135° C. oil bath for 4 days. The amine was removed in vacuo. The product was purified by silica gel chromatography (7:1 hexane:ethyl acetate) to give 25 mg (42%) of N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyridinyl]-2-(2-furyl)pyrazolo[1,5-a]pyridin-7-amine. 1H NMR (CDCl3) δ 8.1 (d, 1H), 7.51 (s, 1H), 7.17 (t, 1H), 6.94 (d, 1H), 6.69 (m, 2H), 6.5 (s, 1H), 6.45 (m, 1H), 6.00 (d, 1H). 5.95 (d, 1H), 4.6 (br d, 1H), 4.0 (m, 1H), 3.92 (m, 1H), 2.19–2.09 (m, 2H), 2.03–1.95 (m, 2H), 1.88–1.43 (m, 8H), 1.32–1.22 (m, 2H);MS m/z 428 (M+1).

Provenance & Evidence