HCID 18446594, compound → HCID 18446595, compound

Participants

Reaction Steps

1-[7-Chloro-2-(2-furyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol (3.63 g, 13.3 mmol) was dissolved in dichloromethane (200 mL) and manganese dioxide (34.7 g, 399 mmol) was added. This slurry was stirred at room temperature for 2 hours. The manganese dioxide was removed by filtration and the filtrate was concentrated to a solid, 1-[7-chloro-2-(3-methyl-2-furyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-one (1.99 g, 55%). 1H NMR (CDCl3): δ 8.54 (d, 1H), 7.65 (d, 1H), 7.62 (d, 1H), 7.49 (t, 1H), 7.21 (d, 1H), 6.58 (m, 1H), 3.35 (s, 1H). MS m/z 271 (M+1).

Provenance & Evidence